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Dr. Jie Zhu

Dr. Jie Zhu

Assistant Professor

Postdoctoral Research Associate: UNC Nutrition Research Institute, University of North Carolina at Chapel Hill
PhD: The First Clinical Medical College, Wuhan University

B.S.: School of Medicine, Wuhan University

Phone: (512) 245-7655

Office: FCS 287J


Dr. Zhu is an Assistant Professor of Nutrition at Texas State University. Dr. Zhu earned his B.S. in Clinical Medicine from School of Medicine and Ph.D. in Internal Medicine with a focus on Gastroenterology and Nutrition from The First Clinical Medical College, Wuhan University. Thereafter, he was awarded a postdoctoral fellowship in Human Nutrition at UNC Nutrition Research Institute, University of North Carolina at Chapel Hill. Before joining in Texas State University, Dr. Zhu was a faculty member in the Department of Nutrition, Shanghai Jiao Tong University School of Medicine.

Dr. Zhu’s research focuses on exploring how diet patterns/nutrients (especially one-carbon metabolism nutrients) and gene interactions affect human chronic diseases risk, and understanding inter-individual differences in nutrients metabolism through a systems biology approach which incorporates various assessments of biochemical, epidemiological, genetic, epigenetic, metabolomic and physiologic endpoints. The goal of this research work is to identify individual genetic factors contributing to diet-related disease risk, understanding inter-individual differences in nutrients metabolism, and exploring effective nutrition intervention programs, which will inform the development of personalized nutrients intake recommendations and ultimately promote human health as well as allow for more effective prevention and/or treatment of human chronic diseases.

Current Projects:

  • Exploring how gene-nutrients interaction in one-carbon metabolism prospectively modify incidence of chronic diseases (e.g., diabetes, cancers, and fatty liver disease) in different large cohorts.
  • Investigating dietary choline intake during pregnancy and choline-metabolizing genetic polymorphisms on risk of gestational diabetes mellitus and their impacts on offspring health.
  • Examining the molecular mechanisms underlying the above gene-nutrients interaction effects on progression of chronic diseases under one-carbon metabolism nutrients (such as choline, betaine) supplementation by conducting in vivo and in vitro studies.

Research Interests:

  • Gene-nutrients interaction and risk of chronic diseases
  • One-carbon metbolism nutrients, epigenetic alterations and metabolic function
  • Maternal and child nutrition

Join Our Team:

We welcome graduate and undergraduate students to assist with current projects. Please email Dr. Zhu to schedule a meeting to discuss volunteer opportunities (


Dr. Zhu is currently seeking opportunities to collaborate with others to understand the role of diet, genetic and metabolic individuality in nutrient metabolism in the development and application of personalized nutrition intervention for prevention and/or treatment of chronic diseases or diseases related to maternal and offspring health. Please email Dr. Zhu at or call 512 245-7655.


  1.  Zhu J, Chen C, Lu L, Yang K, Reis J, He K. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to Diabetes Incidence among American Young Adults: A 30-year Follow-up Study. Diabetes Care. 2020 Jul 31;dc200828. Impact factor (2019): 16.019
  2. Zhu J, Liu YH, He XL, Kohlmeier M, Zhou LL, Shen LW, Yi XX, Tang QY, Cai W, Wang B. Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-control Study. Ann Nutr Metab. 2020; In Press. Impact factor (2019): 2.848
  3. Yang K♯, Zhu J♯, Wu J, Zhong Y, Shen XH, Petrov B, Cai W. Maternal Vitamin D Deficiency Increases Intestinal Permeability and Programs Wnt/ß-catenin Pathway in BALB/C Mice. JPEN J Parenter Enteral Nutr. 2020; doi: 10.1002/jpen.1820. (♯co-first authors). Impact factor (2019): 2.853
  4. Hou J, Wan X, Shen Q, Zhu J, Leng Y, Zhao B, Xia Z, He Y, Wu Y. COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study. Int J Surg. 2020;82:172-178. Impact factor (2019): 3.357
  5. Lu L, Chen C, Yang K, Zhu J, Xun P, Shikany JM, He K. Magnesium intake is inversely associated with risk of obesity in a 30-year prospective follow-up study among American young adults. Eur J Nutr. 2020;10.1007/s00394-020-02206-3. Impact factor (2019): 4.664
  6. Wu K♯, Zhu J♯, Zhou L, Shen L, Gao R, Lou Z, Cai M, Wang B. Lactational changes of fatty acids and fat-soluble antioxidants in human milk from healthy Chinese mothers. Br J Nutr. 2020;123(8):841-848. (♯co-first authors). Impact factor (2019): 3.334
  7. Zhu J, Xun P, Bae JC, Kim JH, Kim DJ, Yang K, He K. Circulating calcium levels and the risk of type 2 diabetes: a systematic review and meta-analysis. Br J Nutr. 2019;122(4):376-387. Impact factor (2018): 3.319
  8. Yang K, Xun P, Carnethon M, Carson AP, Lu L, Zhu J, He K. Low to moderate toenail arsenic levels in young adulthood and incidence of diabetes later in life: findings from the CARDIA Trace Element study. Environ Res. 2019;171:321-327. Impact factor (2018): 5.026
  9. Yan JK, Zhang T, Dai LN, Gu BL, Zhu J, Yan WH, Cai W, Wang Y. CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. FASEB J. 2019 Mar;33(3):3378-3391. Impact factor (2018): 5.391
  10. Zhu J, Lu T, Chen F, Yan JK, Chen F, Zhang QS, Wang JF, Yan WH, Yu TX, Tang QY, Cai W. Choline Protects against Intestinal Failure-associated Liver Disease in Parenteral Nutrition-Fed Immature Rats. JPEN J Parenter Enteral Nutr. 2018;42(2):436-445. Impact factor (2017): 4.249
  11. Yan JK, Zhu J, Gong ZZ, Xiao YT, Cai W. Supplementary Choline Attenuates Olive Oil Lipid Emulsion-induced Enterocyte Apoptosis through Suppression of CELF1/AIF Pathway. J Cell Mol Med. 2018;22(3):1562-1573. Impact factor (2017): 4.439
  12. Wu Y, Xia ZY, Zhao B, Leng Y, Dou J, Meng QT, Chen ZZ, Zhu J*. (-)-Epigallocatechin-3-gallate Attenuates Myocardial Injury Induced by Ischemia/reperfusion under Hyperglycemic Conditions in Diabetic Rats and in H9c2 cells. Int J Mol Med. 2017;40(2):389-399. (*Corresponding author). Impact factor (2016): 2.341
  13.     Wang B, Shen LW, Zhou LL, Wu K, Zhang YH, Cai W, Tang QY, Zhu J*. Association of Choline Intake during Pregnancy and Choline Metabolism in Parturients and Infants. Chin J Perinat Med. 2017;20(11):781-787. (*Corresponding author)(In Chinese)
  14.     Gao RY, Wu K, Zhu J, Cai MQ. Phospholipid Composition of Human Milk at Different Stages of Lactation from women in Shanghai.Journal of Shanghai Jiao Tong University (Medical Science). 2017;37 (8):1151-1155. (In Chinese)
  15.     Zhu J, Wu Y, Guo Y, Tang Q, Lu T, Cai W, Huang H. Choline Alleviates Parenteral Nutrition-Associated Duodenal Motility Disorder in Infant Rats. JPEN J Parenter Enteral Nutr. 2016;40(7):995-1005. Impact factor (2015): 3.517
  16.     Yan JK, Zhu J, Gu BL, Yan WH, Xiao YT, Zhou KJ, Wen J, Wang Y, Cai W. Soybean Oil-Based Lipid Emulsion Increases Intestinal Permeability of Lipopolysaccharide in Caco-2 Cells by Downregulation of P-Glycoprotein via ERK-FOXO 3a Pathway. Cell Physiol Biochem. 2016;39(4):1581-1594. Impact factor (2015): 4.652
  17.  Yu TX, Gu BL, Yan JK, Zhu J, Yan WH, Chen J, Qian LX, Cai W. CUGBP1 and HuR Regulate E-cadherin Translation by Altering Recruitment of E-cadherin mRNA to Processing Bodies and Modulate Epithelial Barrier Function. Am J Physiol Cell Physiol. 2016;310(1):C54-C65. Impact factor (2015): 3.395
  18. Lu T, Chen F, Zhang QS, Wang JF, Chen F, Zhu J*. Investigation of Nutrition Knowledge, Attitude, and Behaviors of Medical Students with Non-nutrition Majors in Shanghai. Journal of Shanghai Jiao Tong University (Medical Science). 2015;35 (8):1238-1242.(*Corresponding author) (In Chinese)
  19. Zhu J, Wu Y, Tang Q, Leng Y, Cai W. Effects of Choline on Hepatic Lipid Metabolism, Mitochondrial Function and Antioxidative Status in Human Hepatic C3A Cells Exposed to Excessive Energy Substrates. Nutrients. 2014;6(7):2552-2571. Impact factor (2013): 4.052
  20. Zhu J, Wu L, Kohlmeier M, Ye F, Cai W. Association between MTHFR C677T, MTHFR A1298C and MS A2756G Polymorphisms and Risk of Cervical Intraepithelial Neoplasia II/III and Cervical Cancer: a Meta-analysis. Mol Med Rep. 2013;8(3):919-927. Impact factor (2012): 1.383
  21. Zhu J, Luo HS, Chen L, Liang CB, Xia H. Effects of Cholecystokinin Octapeptide on the Contractile Activity of Guinea-pig Colonic Smooth Muscles, L-type Calcium Currents and Membrane Potentials of Myocytes. Zhonghua Yi Xue Za Zhi. 2011;91(12):840-844. (In Chinese)
  22. Chen L, Luo HS, Zhu J, Tan W. The Effect of Cholecystokinin on Proximal Colon Myocyte in Guinea-Pigs and Its Mechanism. Zhonghua Xiao Hua Za Zhi. 2011;31(3):178-181. (In Chinese)
  23. Wu Y, Xia ZY, Meng QT, Zhu J, Lei S, Xu J, Dou J. Shen-Fu Injection Preconditioning Inhibits Myocardial Ischemia-Reperfusion Injury in Diabetic Rats: Activation of eNOS via the PI3K/Akt Pathway. J Biomed Biotechnol. 2011;2011:384627. Impact factor (2010): 2.276
  24. Zhu J, Chen L, Xia H, Luo HS. Mechanisms Mediating CCK-8S-induced Contraction of Proximal Colon in Guinea Pigs. World J Gastroenterol. 2010;16(9):1076-1085. Impact factor (2010): 2.731
  25. Zhu J, Luo HS, Chen L, Zhou Ting. Altered Expression of L-type Calcium Channel α1C and α1D Subunits in Colon of Rats with Diarrhea-predominant Irritable Bowel Syndrome. Zhonghua Yi Xue Za Zhi. 2009;89(38):2713-2717. (In Chinese)

Courses Currently Teaching:

  • NUTR 2360 Nutrition Science
  • NUTR 5366 Nutrient Metabolism I

Current Lab Members:

Kallie Lamkin

Lilly Roberts